High-Dose Minocycline Improves Outcomes in Acinetobacter baumannii Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision
High-dose minocycline significantly improved in-hospital survival for A. baumannii group pneumonia. PK/PD-informed breakpoint may offer greater clinical relevance for guiding minocycline therapy compared to CLSI 2024 breakpoint.
Authors
- Yang-Chuan Chen
- Yi‐Tzu Lee (ORCID: https://orcid.org/0000-0002-6183-4987)
- Po-Liang Chen
- Po‐Hsiang Liao (ORCID: https://orcid.org/0000-0002-4266-5428)
- Yung-Chih Wang (ORCID: https://orcid.org/0000-0002-8491-8972)
- Tzu‐Wen Huang (ORCID: https://orcid.org/0000-0002-1229-1138)
- Dung-Hung Chiang
- Yu-Tao Tseng
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Infectious Diseases and Therapy
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s40121-025-01260-w
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00