CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation
CELF1 promotes aerobic glycolysis and aggressive behavior in ER-positive breast cancer, at least partly by regulating GLUT1. These findings reveal RBP-driven metabolic reprogramming in luminal A disease and nominate the CELF1-GLUT1 axis as a potential therapeutic vulnerability.
Authors
- Gena Huang
- Meihua Guo (ORCID: https://orcid.org/0000-0002-8476-6702)
- Jianlei Bi (ORCID: https://orcid.org/0000-0003-4913-0386)
- Bing‐Bing Xu (ORCID: https://orcid.org/0000-0001-8493-342X)
- Jinyu Li (ORCID: https://orcid.org/0000-0002-7693-012X)
- Ning Wang (ORCID: https://orcid.org/0000-0002-2663-7515)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fgene.2025.1687066
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China