Comment on: Predictors of prognosis and overall survival in pediatric mucoepidermoid carcinoma of salivary glands

• Identification of CRTC1/3::MAML2 fusion is critical for confirming mucoepidermoid carcinoma, as morphology alone may not reliably differentiate it from other mucin-secreting salivary gland tumors. • Careful differentiation from entities such as squamous cell carcinoma, adenosquamous carcinoma, and mucinous adenocarcinoma is necessary to avoid inflated reporting of high-grade mucoepidermoid carcinoma. • Genetic markers—including MAML2 fusion status and mutations in KMT2A, PRKD1, FBXW7, and BAP1—are more informative for prognosis than patient age, sex, or tumor laterality.