Pharmacokinetic Evidence Supporting Subcutaneous Use of Protein C Concentrate in Patients with Protein C Deficiency
The PopPK model was robust and described SC protein C concentrate PK data well. Evidence provided by model-based simulations supports the use of various SC dosing regimens across age groups in acute or prophylactic settings according to the intended protein C activity levels. A high loading dose may be required to rapidly attain target therapeutic concentrations.
Authors
- Inmaculada C. Sorribes (ORCID: https://orcid.org/0000-0001-8348-3746)
- Jennifer Schneider (ORCID: https://orcid.org/0000-0002-3473-8009)
- Zhaoyang Li (ORCID: https://orcid.org/0000-0003-4625-1107)
- Adekemi B. Taylor (ORCID: https://orcid.org/0000-0002-7373-5660)
Institutions
- Certara (United States) (US)
- Takeda (United States) (US)
Publication Details
- Journal
- TH Open
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1055/a-2731-5372
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Pharmaceuticals International