Unconscious elevated bottom-up processing in depression: Insights from dynamic causal modeling with EEG and fMRI

This study demonstrates the distinct capabilities of EEG and fMRI data through showing that EEG captures early and fast processing (bottom-up) while fMRI reflects both, bottom-up and top-down regulation. Activity reduction of DLPFC through FFA bottom-up connectivity in early processing (EEG-DCM) might inhibit later top-down emotion regulation through the DLPFC in MDD (fMRI-DCM).

Authors

Michael T. Schaub (ORCID: https://orcid.org/0000-0003-2426-6404)
Lisa Wagels (ORCID: https://orcid.org/0000-0003-4874-4474)
Julia Schräder (ORCID: https://orcid.org/0000-0002-3614-8926)
Thilo Kellermann (ORCID: https://orcid.org/0000-0003-4081-5581)
Damin Kühn
Lennard Rompelberg

Institutions

Jülich Aachen Research Alliance (DE)
RWTH Aachen University (DE)

Publication Details

Journal: Journal of Affective Disorders
Published: 2025-11-11
DOI: https://doi.org/10.1016/j.jad.2025.120638
Primary Topic: Neural and Behavioral Psychology Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Unconscious elevated bottom-up processing in depression: Insights from dynamic causal modeling with EEG and fMRI

Michael T. Schaub, Lisa Wagels, Julia Schräder, Thilo Kellermann et al.

Nov 11, 2025

Journal of Affective Disorders

Neural and Behavioral Psychology Studies

article

Unconscious elevated bottom-up processing in depression: Insights from dynamic causal modeling with EEG and fMRI

Michael T. Schaub, Lisa Wagels, Julia Schräder, Thilo Kellermann, Damin Kühn, Lennard Rompelberg

November 11, 2025article en

Abstract

This study demonstrates the distinct capabilities of EEG and fMRI data through showing that EEG captures early and fast processing (bottom-up) while fMRI reflects both, bottom-up and top-down regulation. Activity reduction of DLPFC through FFA bottom-up connectivity in early processing (EEG-DCM) might inhibit later top-down emotion regulation through the DLPFC in MDD (fMRI-DCM).

Journal of Affective DisordersVol. 394(Pt B)

Jülich Aachen Research Alliance (DE), RWTH Aachen University (DE)

Openalex Percentile: Top 66%

Neural and Behavioral Psychology Studies

DOI Open Access PDF OpenAlex

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