Evaluating the Real-World Value of Daratumumab Addition to Multiple Myeloma Induction Therapy by Real-World Minimal Residual Disease Assessment and Extended Genetic Profiling
Adding daratumumab to VTd improves post-transplant response and MRD negativity in real-world practice. The magnitude of benefit diminishes with increasing numbers of high-risk cytogenetic abnormalities, supporting the value of risk-adapted strategies and real-world MRD assessment in treatment evaluation.
Authors
- Sigurður Y. Kristinsson (ORCID: https://orcid.org/0000-0002-4964-7476)
- Leonora Conneely
- James Croft (ORCID: https://orcid.org/0000-0002-3782-6928)
- Katy Smith
- Kevin Boyd (ORCID: https://orcid.org/0000-0002-5362-6934)
- Pawel Kaczmarek
- Francesca Gay (ORCID: https://orcid.org/0000-0002-8619-412X)
- Edward Renaudon‐Smith (ORCID: https://orcid.org/0000-0002-9673-8274)
- Chin Fen Neoh (ORCID: https://orcid.org/0000-0003-2462-2958)
- Giuseppe Bertuglia (ORCID: https://orcid.org/0009-0009-3785-9824)
- Christina Messiou (ORCID: https://orcid.org/0000-0002-0557-9379)
- Stefania Bonetto
- Guy Pratt (ORCID: https://orcid.org/0000-0002-6937-2852)
- Dingle Spence (ORCID: https://orcid.org/0000-0001-9733-4100)
- Alan Dunlop
- Elisa Seneca
- Charlotte Pawlyn (ORCID: https://orcid.org/0000-0002-7190-0028)
- Martin Kaiser (ORCID: https://orcid.org/0000-0002-3677-4804)
- Jindriska Lindsay
- Emma Nicholson (ORCID: https://orcid.org/0000-0002-6439-0795)
- Tracy Thornton
- Graham Jackson (ORCID: https://orcid.org/0000-0003-0756-969X)
- Mikel Valganon Petrizan
- Lillian M. Fuller
- Lauren Ellis
- TOMMY J. BROWN (ORCID: https://orcid.org/0009-0008-3565-9135)
- Timothy Corbett
- Mark Ethell
- Lewis Vanhinsbergh
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- Frimley Park Hospital (GB)
- East Surrey Hospital (GB)
- Croydon University Hospital (GB)
- Epsom and St Helier University Hospitals NHS Trust (GB)
- East Kent Hospitals University NHS Foundation Trust (GB)
- Turks and Caicos National Museum (TC)
- St Peter's Hospital (GB)
- National University Hospital of Iceland (IS)
- Royal Marsden Hospital (GB)
- Kingston Hospital (GB)
- Royal Surrey NHS Foundation Trust (GB)
- University Hospitals Sussex NHS Foundation Trust (GB)
- University of Turin (IT)
- Newcastle University (GB)
Publication Details
- Journal
- Clinical Lymphoma Myeloma & Leukemia
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.clml.2025.11.003
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00