Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation

TET2 mutations promote antitumor leukocyte states that can potentiate the efficacy of immunotherapy with checkpoint blockade. See related commentary by Yuan and Guryanova, p. 825.

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Publication Details

Journal
Cancer Research
Published
2025-11-11
DOI
https://doi.org/10.1158/0008-5472.can-24-3329
Citations
2
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
2.09
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article

Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation

Sagi Abelson, Robert J. Vanner, Lixia Jin, Marcus O. Butler et al.
2 citations
Cancer Research
CAR-T cell therapy research
2.09
article

Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation

Sagi Abelson, Robert J. Vanner, Lixia Jin, Marcus O. Butler, Elisa Donato, Caitlyn Vlasschaert, Mark D. Minden, Michelle Chan‐Seng‐Yue, Suraj Bansal, Enrique Sanz‐García, Liran I. Shlush, Sofia Genta, Steven M. Chan, Michael J. Rauh, Yitong Yang, Maurício Fernando Silva Almeida Ribeiro, Samuel D. Saibil, Andy G.X. Zeng, Andreas Trumpp, Patrick Stelmach, Meghan Kates, John E. Dick, Marco M. Buttigieg, Vincent Rondeau, Aarushi Gupta, Jessica McLeod, Darryl Y. Chan
article en
2 citations

Abstract

TET2 mutations promote antitumor leukocyte states that can potentiate the efficacy of immunotherapy with checkpoint blockade. See related commentary by Yuan and Guryanova, p. 825.

Cancer ResearchVol. 86(4)
Ontario Institute for Cancer Research (CA), University Health Network (CA), German Cancer Research Center (DE), University of Toronto (CA), Queen's University (CA), Heidelberg University (DE), Princess Margaret Cancer Centre (CA), Moffitt Cancer Center (US), DKFZ-ZMBH Alliance (DE), Heidelberg Institute for Stem Cell Technology and Experimental Medicine (DE), Deutsches Konsortium für Translationale Krebsforschung (DE), Weizmann Institute of Science (IL)
Openalex Percentile: Top 10%
CAR-T cell therapy research
2.09
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