Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation
TET2 mutations promote antitumor leukocyte states that can potentiate the efficacy of immunotherapy with checkpoint blockade. See related commentary by Yuan and Guryanova, p. 825.
Authors
- Sagi Abelson (ORCID: https://orcid.org/0000-0003-1747-3819)
- Robert J. Vanner (ORCID: https://orcid.org/0000-0003-1169-1778)
- Lixia Jin (ORCID: https://orcid.org/0000-0001-8018-9779)
- Marcus O. Butler (ORCID: https://orcid.org/0000-0002-9840-7057)
- Elisa Donato (ORCID: https://orcid.org/0000-0003-3541-9170)
- Caitlyn Vlasschaert (ORCID: https://orcid.org/0009-0003-8466-7602)
- Mark D. Minden (ORCID: https://orcid.org/0000-0002-9089-8816)
- Michelle Chan‐Seng‐Yue (ORCID: https://orcid.org/0000-0003-3773-9354)
- Suraj Bansal (ORCID: https://orcid.org/0000-0003-4023-6635)
- Enrique Sanz‐García (ORCID: https://orcid.org/0000-0002-3119-3832)
- Liran I. Shlush (ORCID: https://orcid.org/0000-0002-3700-270X)
- Sofia Genta (ORCID: https://orcid.org/0000-0001-8441-2456)
- Steven M. Chan (ORCID: https://orcid.org/0000-0002-4354-0731)
- Michael J. Rauh (ORCID: https://orcid.org/0000-0002-8346-5537)
- Yitong Yang (ORCID: https://orcid.org/0000-0002-5953-9858)
- Maurício Fernando Silva Almeida Ribeiro (ORCID: https://orcid.org/0000-0002-5602-164X)
- Samuel D. Saibil (ORCID: https://orcid.org/0000-0002-4477-8258)
- Andy G.X. Zeng (ORCID: https://orcid.org/0000-0002-3223-6400)
- Andreas Trumpp (ORCID: https://orcid.org/0000-0002-6212-3466)
- Patrick Stelmach (ORCID: https://orcid.org/0009-0000-5270-4761)
- Meghan Kates (ORCID: https://orcid.org/0000-0002-3976-4919)
- John E. Dick (ORCID: https://orcid.org/0000-0002-9527-8317)
- Marco M. Buttigieg (ORCID: https://orcid.org/0000-0002-9584-9861)
- Vincent Rondeau (ORCID: https://orcid.org/0000-0002-9513-5703)
- Aarushi Gupta (ORCID: https://orcid.org/0009-0001-8068-2528)
- Jessica McLeod (ORCID: https://orcid.org/0009-0003-4669-5100)
- Darryl Y. Chan (ORCID: https://orcid.org/0009-0008-8047-0454)
Institutions
- Ontario Institute for Cancer Research (CA)
- University Health Network (CA)
- German Cancer Research Center (DE)
- University of Toronto (CA)
- Queen's University (CA)
- Heidelberg University (DE)
- Princess Margaret Cancer Centre (CA)
- Moffitt Cancer Center (US)
- DKFZ-ZMBH Alliance (DE)
- Heidelberg Institute for Stem Cell Technology and Experimental Medicine (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Weizmann Institute of Science (IL)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3329
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09