NHC-Catalyzed Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes
1,2,4-Oxadiazoles are key scaffolds in natural products and bioactive molecules. This study reports an efficient NHC-catalyzed [4 + 1] cyclization from accessible aldehydes and amidoximes to build it, concisely synthesizing tioxazafen, ataluren, and an mGluR5 antagonist. Broad substrate scope and gram-scale transformations confirm efficiency and practicality.
Authors
- Zhenqian Fu (ORCID: https://orcid.org/0000-0002-3806-6684)
- Haibin Zhu (ORCID: https://orcid.org/0009-0002-1578-5587)
Institutions
- Nanjing Tech University (CN)
- The Synergetic Innovation Center for Advanced Materials (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1021/acs.orglett.5c04219
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00