Factors Associated With Early Detection of Clinically Significant Prostate Cancer After a Negative Magnetic Resonance Imaging–Informed Biopsy
Higher PSA density, PI-RADS 4 to 5 on baseline mpMRI, and absence of inflammation on baseline biopsy were associated with detection of csPCa. Persistent PI-RADS 4 to 5 on repeat mpMRI further increased risk. High-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation were not associated with csPCa detection.
Authors
- Edward M. Schaeffer (ORCID: https://orcid.org/0000-0003-0699-1899)
- Ridwan Alam (ORCID: https://orcid.org/0000-0001-7805-9596)
- Mitchell M. Huang (ORCID: https://orcid.org/0000-0002-5993-6415)
- Jennifer Slota (ORCID: https://orcid.org/0000-0003-0036-2979)
- Yutai Li (ORCID: https://orcid.org/0000-0002-9190-4755)
- Hiten D. Patel (ORCID: https://orcid.org/0000-0003-4028-010X)
- Sai Kumar (ORCID: https://orcid.org/0000-0002-3577-3543)
- Ashley E Ross
- Nicole Handa (ORCID: https://orcid.org/0000-0002-0700-7200)
- Jae Woong Jang (ORCID: https://orcid.org/0009-0003-6898-6785)
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Urology Practice
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1097/upj.0000000000000918
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00