Perioperative Blood Transfusion, Postoperative Hemoglobin, and Clinical Outcomes in Neonates: A Retrospective Observational Study From a Large Quaternary Hospital
We report >22% of neonates were exposed to a RBC transfusion perioperatively in our entire surgical cohort with an incidence of >50% of those transfused being over transfused to Hb levels ≥12.0 g/dL. Our results suggest that transfusion volumes >25 mL/kg may be associated with worse outcomes. Our findings underscore the need for comprehensive evidence-based patient blood management strategies to clearly define acceptable perioperative conservative RBC transfusion thresholds and minimize unnecessary transfusions in neonates.
Authors
- Samir C. Seshadri
- Steven J. Staffa (ORCID: https://orcid.org/0000-0002-7588-7596)
- Susan M. Goobie (ORCID: https://orcid.org/0000-0001-8697-089X)
- Martha Sola‐Visner (ORCID: https://orcid.org/0000-0002-0013-598X)
- Joseph P. Cravero (ORCID: https://orcid.org/0000-0003-0629-6511)
- Anna Kordun
- Patricia Ellen Davenport (ORCID: https://orcid.org/0000-0003-1230-504X)
- Qinglan Huang
Institutions
- European Organisation for Research and Treatment of Cancer (NL)
- Boston Children's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Center for Pain and the Brain (US)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1213/ane.0000000000007825
- Citations
- 2
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 1.55