Extracellular vesicles derived from M1 macrophages deliver MPPED2 and regulate PI3K/AKT to suppress trophoblast autophagy and proliferation in recurrent spontaneous abortion
Our findings suggest that MPPED2 from exosomes plays an important role in intercellular communication between M1 macrophages and the trophoblast, elucidating a novel mechanism by which M1 macrophages regulate trophoblast function and its role in recurrent spontaneous abortion.
Authors
- Cen Tang
- Hongbo Qi (ORCID: https://orcid.org/0000-0002-4911-7942)
Institutions
- Chongqing Maternal and Child Health Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Biology of Reproduction
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/biolre/ioaf249
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00