Synergistic Photocatalysis of Acridinium Salts and Pyridine <i>N</i> -Oxides for α-Aminoalkylation with <i>N</i> -Methylsulfonamides
This study presents a synergistic photocatalytic method using acridinium salts and pyridine <i>N</i>-oxides for the Giese reaction between <i>N</i>-methylsulfonamides and olefins, which utilizes <i>N</i>-methylsulfonamides as α-aminoalkylating reagents. Notable features of this approach include mild reaction conditions, excellent atom economy, good site selectivity, a broad substrate scope, and the ability to enable postmodification of complex drug fragments.
Authors
- Lipeng Qiao
- Kai Sun (ORCID: https://orcid.org/0000-0003-2135-0838)
- Bing Yu (ORCID: https://orcid.org/0000-0002-2423-1212)
- Zi Yang (ORCID: https://orcid.org/0000-0002-8377-118X)
- Xi Chen (ORCID: https://orcid.org/0000-0001-7303-148X)
- Xiaolan Chen (ORCID: https://orcid.org/0000-0002-3061-8456)
- Zhichao Zhang (ORCID: https://orcid.org/0009-0008-5827-8837)
- Lingbo Qu
- Wumeng Yang
Institutions
- Changsha Medical University (CN)
- Nanjing Forestry University (CN)
- Hunan Normal University (CN)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1021/acs.joc.5c01813
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81