Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications
This study reveals that CIITA-induced antigen presentation in macrophages activates local T-cell inflammatory response, promoting plaque progression. Targeting this pathway may improve vaccination efficacy by creating anti-inflammatory niches within plaques, offering a novel therapeutic strategy for atherosclerosis.
Authors
- Lianping Cheng (ORCID: https://orcid.org/0009-0007-0941-5711)
- Yuhuai Xie (ORCID: https://orcid.org/0000-0001-7280-7098)
- Yuanyuan Wei (ORCID: https://orcid.org/0000-0003-0635-6879)
- Xian Yang (ORCID: https://orcid.org/0009-0005-2625-4468)
- W.-P. Wang (ORCID: https://orcid.org/0000-0001-7757-772X)
- Wei Xu (ORCID: https://orcid.org/0000-0003-1226-097X)
- Zhen Zhao (ORCID: https://orcid.org/0000-0002-4959-452X)
- Yunhui Jia (ORCID: https://orcid.org/0009-0001-8019-1585)
- Que Wu (ORCID: https://orcid.org/0009-0009-6008-879X)
- Yaru Tian (ORCID: https://orcid.org/0009-0000-5962-6890)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Guangzhou Experimental Station (CN)
- Shanghai Ninth People's Hospital (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Zhongshan Hospital (CN)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1093/eurheartj/ehaf878
- Citations
- 2
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.59