Limited sensitivity of somatosensory evoked potentials as disease monitoring biomarkers in hereditary spastic paraplegias
The neurophysiological progression of sensory long tract dysfunction is even slower than the progression of motor findings measured by COAs in HSP. The low sensitivity to change of SSEPs identified suggests that they should not be used as primary endpoints in future clinical trials for disease-modifying drugs.
Authors
- Isabela Possebon Bevilacqua
- Ana Luiza Rodrigues Louzada
- Diana Maria Cubillos-Arcila (ORCID: https://orcid.org/0000-0001-9777-152X)
- F Spengler (ORCID: https://orcid.org/0000-0003-3329-2866)
- Samanta Ferraresi Brighente
- Jonas Alex Morales Saute (ORCID: https://orcid.org/0000-0003-1141-6573)
- Maria Mirian de Souza (ORCID: https://orcid.org/0009-0000-2802-7385)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Hospital de Clínicas de Porto Alegre (BR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1371/journal.pone.0335187
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Hospital de Clínicas de Porto Alegre
- Fundação Instituto de Pesquisas Econômicas