Ulinastatin attenuates perioperative nitric oxide surge and postoperative delirium in cardiac surgery: a prospective cohort study with molecular docking and experimental validation
Dynamic perioperative NO surges independently predict POD and postoperative mortality in cardiac surgery. Ulinastatin mitigates this risk by suppressing pathological NO elevation and preserving endothelial integrity, supporting a biomarker-guided neuroprotection strategy.
Authors
- Fang Luo (ORCID: https://orcid.org/0000-0002-0444-7972)
- Lingzhong Meng (ORCID: https://orcid.org/0000-0002-5168-5084)
- Tingting Xu (ORCID: https://orcid.org/0000-0002-9721-3971)
- Qin Zhang (ORCID: https://orcid.org/0000-0002-7083-8947)
- Hang Ruan (ORCID: https://orcid.org/0000-0001-7738-0177)
- Xiao Ran (ORCID: https://orcid.org/0000-0001-5025-2538)
- Juan Tan
- Jieqiong Liu
- Ping Yang (ORCID: https://orcid.org/0009-0007-7144-189X)
Institutions
- Tongji Hospital (CN)
- Indiana University School of Medicine
- Huazhong University of Science and Technology (CN)
- Indiana University – Purdue University Indianapolis (US)
- Xiaomi (China) (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1097/js9.0000000000004039
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00