Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
Our findings suggested that expanded mCAs were significantly associated with all-cause and cause-specific deaths and could serve as a complement to the FI in providing a more comprehensive perspective on mortality risk, especially for cancer mortality.
Authors
- Iain Turnbull (ORCID: https://orcid.org/0000-0002-9913-1961)
- Jieming Zhong (ORCID: https://orcid.org/0000-0001-8987-2216)
- Sam Morris
- Yan Lu (ORCID: https://orcid.org/0000-0003-1183-875X)
- Xianping Wu (ORCID: https://orcid.org/0000-0002-9806-5309)
- Dewei Zheng
- Shuai Yang (ORCID: https://orcid.org/0000-0001-9637-7758)
- Kaifei Zhu
- Shaofang Li (ORCID: https://orcid.org/0000-0002-1903-023X)
- Chikashi C. Terao (ORCID: https://orcid.org/0000-0002-6452-4095)
- Lingfeng He (ORCID: https://orcid.org/0000-0003-2763-1462)
- Daniel Avery (ORCID: https://orcid.org/0000-0002-9823-9575)
- Mohsen Mazidi (ORCID: https://orcid.org/0000-0003-3059-229X)
- Huiming Luo
- Giulio Genovese (ORCID: https://orcid.org/0000-0003-3066-5575)
- Xikang Fan (ORCID: https://orcid.org/0000-0002-9944-284X)
- Charlotte Clarke
- Kai Kang (ORCID: https://orcid.org/0000-0003-2464-2983)
- Yuan Cao (ORCID: https://orcid.org/0000-0002-5635-9253)
- Chen Hu
- Andri Iona (ORCID: https://orcid.org/0000-0001-8042-9672)
- Dongyang Zhao (ORCID: https://orcid.org/0000-0002-7079-784X)
- Yan Zha (ORCID: https://orcid.org/0000-0002-8713-1665)
- Bin He (ORCID: https://orcid.org/0000-0002-7690-4730)
- Pek Kei Im (ORCID: https://orcid.org/0000-0002-2624-9766)
- Jun Lv (ORCID: https://orcid.org/0000-0003-2337-9570)
- Wei Tang (ORCID: https://orcid.org/0009-0009-6478-8056)
- Juping Ma
- Jianrong Jin
- Jinyan Chen (ORCID: https://orcid.org/0000-0003-4103-7056)
- Jinchao Liu (ORCID: https://orcid.org/0009-0006-8279-6285)
- Zengchang Pang (ORCID: https://orcid.org/0000-0003-4746-0074)
- Liyuan Zhou (ORCID: https://orcid.org/0000-0001-8042-6949)
- Peter Lou
- Johnathan Clarke
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Dan Schmidt (ORCID: https://orcid.org/0000-0003-0704-8165)
- Yuxiao Huang
- Kuang Lin (ORCID: https://orcid.org/0000-0002-7360-3385)
- Jinyi Zhou (ORCID: https://orcid.org/0000-0001-6057-862X)
- Xiaoyu Chang (ORCID: https://orcid.org/0009-0008-4333-0559)
- Qiang Jiang (ORCID: https://orcid.org/0000-0002-1485-0909)
- Chunxiao Xu (ORCID: https://orcid.org/0000-0003-3592-7423)
- Huijuan Feng (ORCID: https://orcid.org/0000-0002-9087-2405)
- Mengwei Wang (ORCID: https://orcid.org/0000-0001-8412-9706)
- Xukui Zhang
- Zhaodong Wang (ORCID: https://orcid.org/0009-0008-1111-6742)
- Douer Zhu (ORCID: https://orcid.org/0000-0001-8505-2384)
- Richard Peto (ORCID: https://orcid.org/0000-0001-8219-5339)
- Yuxuan Zhao (ORCID: https://orcid.org/0000-0003-2776-6199)
- Maryam Rahmati (ORCID: https://orcid.org/0000-0001-8825-1565)
- Alfred Pozarickij (ORCID: https://orcid.org/0000-0002-6937-8496)
- Yilei Li (ORCID: https://orcid.org/0000-0002-9786-1127)
- Pang Yao (ORCID: https://orcid.org/0000-0002-6875-7435)
- Hannah Fry (ORCID: https://orcid.org/0009-0006-1584-2042)
- Christiana Kartsonaki (ORCID: https://orcid.org/0000-0002-3981-3418)
- Maria Kakkoura (ORCID: https://orcid.org/0000-0003-3688-1367)
- Zhenzhen Lu
- Hua Zhang (ORCID: https://orcid.org/0000-0002-4158-8387)
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Kailash Kolhe (ORCID: https://orcid.org/0000-0003-3520-8277)
- Tingting Ou
- Yuting Han (ORCID: https://orcid.org/0009-0009-0705-4224)
- Lei Yin
- Mingqiang Yuan
- Robin G. Walters (ORCID: https://orcid.org/0000-0002-9179-0321)
- Changping Xie
- Derrick Bennett (ORCID: https://orcid.org/0000-0002-9170-8447)
- Ruth Boxall (ORCID: https://orcid.org/0000-0003-0356-3549)
- Xiaoyan Zheng (ORCID: https://orcid.org/0000-0002-8189-6210)
- Xiaoxu Shen (ORCID: https://orcid.org/0000-0003-3729-8691)
- Faqing Chen (ORCID: https://orcid.org/0000-0002-9026-2957)
- Baihan Wang (ORCID: https://orcid.org/0000-0001-6986-8236)
- Hubert Lam (ORCID: https://orcid.org/0000-0003-1228-3362)
- Yuanyuan Jin
- Zhenyuan Wu (ORCID: https://orcid.org/0009-0000-3278-3642)
- Neil Wright (ORCID: https://orcid.org/0000-0002-3946-1870)
- Hua Bian (ORCID: https://orcid.org/0000-0001-8449-0665)
- Zong-Ming Cheng
- Ying Li (ORCID: https://orcid.org/0000-0002-0572-5444)
- Qunhua Nie
- Yujin He
- Robert B. Clarke (ORCID: https://orcid.org/0000-0001-5407-3123)
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Tingping Zhu (ORCID: https://orcid.org/0000-0003-3777-0888)
- Ruying Hu (ORCID: https://orcid.org/0000-0001-5928-9193)
- Liuping Wei
- Yuan Bo Peng (ORCID: https://orcid.org/0000-0002-3124-859X)
- Mingyu Song (ORCID: https://orcid.org/0000-0002-6833-8329)
- Weijie Hu
- Huizi Tian
- Xia Wu (ORCID: https://orcid.org/0000-0002-2056-8344)
- Zhiwei Han (ORCID: https://orcid.org/0000-0002-8155-929X)
- Jian‐Jun Feng (ORCID: https://orcid.org/0000-0002-6094-3268)
- Ran Tao (ORCID: https://orcid.org/0000-0002-1106-2923)
- Yuanjie Pang (ORCID: https://orcid.org/0000-0003-1328-3700)
- Xiaocong Zhao (ORCID: https://orcid.org/0000-0003-3313-3566)
- Lang Pan (ORCID: https://orcid.org/0000-0002-5231-367X)
- Ahmed Edris Mohamed
- Yi Liu (ORCID: https://orcid.org/0000-0003-4030-9670)
- Xiaojun Li (ORCID: https://orcid.org/0000-0002-7526-0558)
- Libo Zhang (ORCID: https://orcid.org/0000-0002-8601-7705)
- Xiaolin Li (ORCID: https://orcid.org/0000-0001-9314-5716)
- Xinxin Chen (ORCID: https://orcid.org/0000-0003-3279-5314)
- Xing Li (ORCID: https://orcid.org/0000-0003-3793-1581)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Yiping Chen (ORCID: https://orcid.org/0000-0003-3602-5165)
- Meng Wang (ORCID: https://orcid.org/0000-0002-4970-8590)
- Yuan Liu (ORCID: https://orcid.org/0000-0002-6044-4848)
- Chen Chen (ORCID: https://orcid.org/0000-0003-2104-534X)
- Liming Li (ORCID: https://orcid.org/0000-0002-5798-2362)
- Zhuo Wang (ORCID: https://orcid.org/0000-0002-4069-9501)
- Dingwei Sun
- Xiao Han (ORCID: https://orcid.org/0000-0002-6024-6286)
- Qiang Sun (ORCID: https://orcid.org/0000-0001-8913-5099)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-9437-6452)
- Yanling Chen (ORCID: https://orcid.org/0000-0002-6387-8561)
- Shuxian Wang (ORCID: https://orcid.org/0000-0001-7570-668X)
- Jun Wang (ORCID: https://orcid.org/0000-0002-4606-5585)
- Huilin Liu
- Yongmei Liu (ORCID: https://orcid.org/0000-0002-6562-1858)
- Shaojie Wang (ORCID: https://orcid.org/0000-0003-2706-3581)
- Jian Su (ORCID: https://orcid.org/0000-0001-8859-2343)
- Chao Liu (ORCID: https://orcid.org/0009-0009-6163-641X)
- Shixian Feng (ORCID: https://orcid.org/0000-0003-1380-2742)
- Jing Wang (ORCID: https://orcid.org/0000-0003-2891-670X)
- Bing Han (ORCID: https://orcid.org/0000-0001-7600-6693)
- James Hou-fu Liu (ORCID: https://orcid.org/0000-0001-9520-5727)
- Wanshen Guo
- Lin Yang (ORCID: https://orcid.org/0000-0002-7358-7872)
- Chan Qu
- Can Hou (ORCID: https://orcid.org/0000-0002-9872-786X)
- L. Zhai
- Jian Lan
- Junshi Chen (ORCID: https://orcid.org/0000-0001-5530-1343)
- Weiwei Gong (ORCID: https://orcid.org/0000-0002-7066-4772)
- Lijun Chang (ORCID: https://orcid.org/0000-0001-9421-7013)
- Hao Xu (ORCID: https://orcid.org/0000-0003-1752-2035)
- Yujie Hua (ORCID: https://orcid.org/0009-0007-7879-1681)
- Li Gao (ORCID: https://orcid.org/0000-0002-5945-8310)
- Shanpeng Li (ORCID: https://orcid.org/0000-0002-0857-7598)
- Lin Wang (ORCID: https://orcid.org/0000-0002-2610-695X)
- Ka Hung Chan (ORCID: https://orcid.org/0000-0002-6958-9349)
- Fei Wang (ORCID: https://orcid.org/0000-0001-6580-1552)
- Song Dong (ORCID: https://orcid.org/0000-0002-5213-5121)
- Lingli Chen (ORCID: https://orcid.org/0009-0000-4575-690X)
- Ruqin Gao (ORCID: https://orcid.org/0000-0002-3845-7829)
- Dan Hu (ORCID: https://orcid.org/0000-0002-4614-4785)
- Xueyun Wang (ORCID: https://orcid.org/0000-0001-7553-171X)
- Hesheng Zhang
- Yalin Chen (ORCID: https://orcid.org/0000-0002-4265-1018)
- Hongfu Ren
- Xiangyang Zheng (ORCID: https://orcid.org/0000-0003-3346-3979)
- Dianjianyi Sun
- Wei Mao (ORCID: https://orcid.org/0000-0002-8563-3952)
- Pan He (ORCID: https://orcid.org/0000-0002-6623-3048)
- Fudi Zhong (ORCID: https://orcid.org/0000-0003-2606-1285)
- Lifang Zhou (ORCID: https://orcid.org/0000-0002-0887-7451)
- Ke Gong (ORCID: https://orcid.org/0000-0002-8355-6770)
- Xiaolan Ren
- Bo Xiao (ORCID: https://orcid.org/0009-0003-3512-8645)
- Sisi Wang (ORCID: https://orcid.org/0009-0007-8201-6442)
- Li Yin
- Yan Ya-li
- Xiaoming Cui
- Xiaocao Tian
- Maxim Barnard (ORCID: https://orcid.org/0009-0004-5160-6632)
- Wei Sun (ORCID: https://orcid.org/0000-0003-1416-3313)
- Jinxue Tan
- Xian Xie
- Paul Ryder
- Qingmei Xia
- Zilun Shao (ORCID: https://orcid.org/0009-0002-9807-8975)
- Shichun Yan
- Linqi Diao
- Xiaoming Yang
- Xiaofei Tu (ORCID: https://orcid.org/0009-0008-0960-4771)
- Rory Collins
- Kaixu Xie
- Simon Gilbert
- Huarong Sun
- Ge Zhong
- Lihui Li (ORCID: https://orcid.org/0000-0002-2229-9221)
- Haiping Duan
- Xiaofang Zhang
- Ningmei Zhang
- Becky Stevens
- Liang Cheng (ORCID: https://orcid.org/0000-0003-4288-1486)
- Ling Yang (ORCID: https://orcid.org/0009-0008-8832-9682)
- Yujie Wang (ORCID: https://orcid.org/0009-0009-6010-2571)
- Chi Wang (ORCID: https://orcid.org/0009-0009-5842-1274)
- Hao Wang (ORCID: https://orcid.org/0009-0008-4494-6793)
- Pei Pei (ORCID: https://orcid.org/0000-0002-5741-6563)
Institutions
- Broad Institute (US)
- Harvard University (US)
- University of Shizuoka (JP)
- Peking University (CN)
- University of Oxford (GB)
- Ministry of Education (RO)
- China National Center for Food Safety Risk Assessment (CN)
- Shizuoka General Hospital (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Henan Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12916-025-04452-w
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research UK
- University of Oxford
- National Natural Science Foundation of China
- Chinese Center for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Medical Research Council
- National Key Research and Development Program of China