pH-responsive Oral liposomal delivery of hydrogen sulfide donor GYY4137 enables colon-targeted therapy for inflammatory bowel disease
These findings demonstrate that Oral H₂S lipo enables effective, site-specific delivery of H₂S to inflamed colonic tissue, offering a clinically relevant platform to overcome limitations of conventional H₂S donor therapies in IBD management.
Authors
- Haena Park (ORCID: https://orcid.org/0000-0003-3641-7337)
- Hyung‐Jun Im (ORCID: https://orcid.org/0000-0002-4368-6685)
- Seo‐young Silvia Kim (ORCID: https://orcid.org/0000-0002-8801-9210)
- Jee-Eun Hwang
- Jae Kyoo Lee (ORCID: https://orcid.org/0000-0002-1257-8737)
- H.J. Yim
- Chiwoo Oh
Institutions
- Seoul National University of Science and Technology (KR)
- Boston Children's Hospital (US)
- Harvard University (US)
- Seoul National University (KR)
- Cancer Research Institute (US)
- Advanced Institute of Convergence Technology (KR)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s12951-025-03753-9
- Citations
- 2
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- National Research Foundation
- Ministry of Trade, Industry and Energy
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Korea Drug Development Fund
- Ministry of Science and ICT, South Korea
- Korea Evaluation Institute of Industrial Technology