Effect of Paracetamol on Cerebral Temperature in Febrile Brain-Injured Patients. The NEUROTHERM Study: A Randomized Controlled Pharmacodynamic Trial

Paracetamol significantly reduced CT in febrile brain-injured patients (overall mean reduction of 0.6°C), maintaining temperatures less than 38.5°C for a median of 3.6 hours. The gradient between CT and ST was consistently about 0.3°C in both groups.

Authors

Mickaela Roy
Stéphane Welschbillig
Chloé Le Cossec
Marine De Mesmay
Nicolas Engrand (ORCID: https://orcid.org/0000-0002-6051-5474)
Charles Grégoire (ORCID: https://orcid.org/0009-0002-2164-1184)
Laurane Geral

Institutions

Fondation de Rothschild (FR)

Publication Details

Journal: Critical Care Medicine
Published: 2025-11-11
DOI: https://doi.org/10.1097/ccm.0000000000006951
Primary Topic: Thermal Regulation in Medicine
Type: article
Field-Weighted Citation Impact: 0.00

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article

Effect of Paracetamol on Cerebral Temperature in Febrile Brain-Injured Patients. The NEUROTHERM Study: A Randomized Controlled Pharmacodynamic Trial

Mickaela Roy, Stéphane Welschbillig, Chloé Le Cossec, Marine De Mesmay et al.

Nov 11, 2025

Critical Care Medicine

Thermal Regulation in Medicine

article

Effect of Paracetamol on Cerebral Temperature in Febrile Brain-Injured Patients. The NEUROTHERM Study: A Randomized Controlled Pharmacodynamic Trial

Mickaela Roy, Stéphane Welschbillig, Chloé Le Cossec, Marine De Mesmay, Nicolas Engrand, Charles Grégoire, Laurane Geral

November 11, 2025article en

Abstract

Paracetamol significantly reduced CT in febrile brain-injured patients (overall mean reduction of 0.6°C), maintaining temperatures less than 38.5°C for a median of 3.6 hours. The gradient between CT and ST was consistently about 0.3°C in both groups.

Critical Care MedicineVol. 54(1)

Fondation de Rothschild (FR)

Openalex Percentile: Top 61%

Thermal Regulation in Medicine

DOI Source OpenAlex

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