The effects of progesterone supplementation in pregnancies assessed by doppler ultrasound: a systematic review of maternal and perinatal outcomes

Progesterone supplementation in early and mid-pregnancy may benefit certain subgroups, particularly those at risk of preterm birth. However, its overall effectiveness in improving clinical outcomes is unclear. More research using standardized progesterone regimens is needed to better understand its role in pregnancy management. Progesterone supplementation may help prevent preterm birth in high-risk populations, such as women with a short cervix. However, Doppler ultrasound findings should not be the sole factor in guiding its use. However, its role in improving other clinical outcomes, such as IUGR and preeclampsia, remains uncertain. Obstetricians should consider progesterone use as part of individualized treatment plans, particularly for women at high risk for preterm birth.

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Publication Details

Journal
European journal of medical research
Published
2025-11-11
DOI
https://doi.org/10.1186/s40001-025-03382-w
Citations
1
Primary Topic
Preterm Birth and Chorioamnionitis
Type
article
Field-Weighted Citation Impact
1.35
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article

The effects of progesterone supplementation in pregnancies assessed by doppler ultrasound: a systematic review of maternal and perinatal outcomes

Nazanin Sadraei, Sahar Sadat Moosavi, Somayeh Khanjani, Mobina Fathi et al.
1 citations
European journal of medical research
Preterm Birth and Chorioamnionitis
1.35
article

The effects of progesterone supplementation in pregnancies assessed by doppler ultrasound: a systematic review of maternal and perinatal outcomes

Nazanin Sadraei, Sahar Sadat Moosavi, Somayeh Khanjani, Mobina Fathi, Reza Eshraghi, Maryam Nasr Azadani, Mohammad Mehdi Khaleghi, Ashkan Bahrami, S. Goodarzi, Mohammad Saeed Soleimani Meigoli
article en
1 citations

Abstract

Progesterone supplementation in early and mid-pregnancy may benefit certain subgroups, particularly those at risk of preterm birth. However, its overall effectiveness in improving clinical outcomes is unclear. More research using standardized progesterone regimens is needed to better understand its role in pregnancy management. Progesterone supplementation may help prevent preterm birth in high-risk populations, such as women with a short cervix. However, Doppler ultrasound findings should not be the sole factor in guiding its use. However, its role in improving other clinical outcomes, such as IUGR and preeclampsia, remains uncertain. Obstetricians should consider progesterone use as part of individualized treatment plans, particularly for women at high risk for preterm birth.

European journal of medical researchVol. 30(1)
Isfahan University of Medical Sciences (IR), Shiraz University of Medical Sciences (IR), Shahid Chamran University of Ahvaz (IR), Kashan University of Medical Sciences (IR), University of Tehran (IR), Fasa University of Medical Sciences (IR), Shahid Beheshti University of Medical Sciences (IR), Persian Gulf University (IR)
Openalex Percentile: Top 14%
Preterm Birth and Chorioamnionitis
1.35
DOIOpen Access PDFOpenAlex
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