Thrombomodulin is essential for recombinant Fc-fusion protein production in Chinese hamster ovary cells via multiple signaling pathways
This study demonstrates the essential role of thrombomodulin in recombinant Fc-fusion protein production in Chinese hamster ovary cells, reveals novel biological functions of thrombomodulin, and expands our understanding of the complex cellular machinery underlying recombinant protein expression in CHO cells.
Authors
- N Wang
- Xiaonan Ma (ORCID: https://orcid.org/0000-0002-3591-2451)
- Ningning Ma (ORCID: https://orcid.org/0000-0002-1682-4149)
- Shuang Li (ORCID: https://orcid.org/0000-0002-4963-9273)
- Rong Xiao (ORCID: https://orcid.org/0000-0002-0603-9518)
- Linxiang Zhao (ORCID: https://orcid.org/0000-0003-1045-5781)
- Mingqi Wang (ORCID: https://orcid.org/0000-0003-4586-8594)
- Qihang Yan
- Guorong Hu
Institutions
- Shenyang Pharmaceutical University (CN)
Publication Details
- Journal
- Journal of Biological Engineering
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s13036-025-00576-y
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00