Time matters: The prognostic impact of diagnostic delay on survival in primary central nervous system lymphoma—a single-center, retrospective real-world study
Our study underscores the prognostic impact of diagnostic delay in PCNSL. Renal function and KPS emerged as independent OS markers. MTX-based chemotherapy remains the standard of care, with autologous hematopoietic stem cell transplantation providing best survival outcomes in eligible patients.
Authors
- Louisa Lehner (ORCID: https://orcid.org/0009-0000-0524-4985)
- Patrick N. Harter (ORCID: https://orcid.org/0000-0001-5530-6910)
- Abdul Qayyum Khan (ORCID: https://orcid.org/0000-0002-4153-0548)
- Louisa von Baumgarten (ORCID: https://orcid.org/0000-0002-6634-0927)
- Benjamin Englert (ORCID: https://orcid.org/0000-0002-1769-5393)
- Andreas Straube (ORCID: https://orcid.org/0000-0002-1695-1666)
- Martin H. Dreyling (ORCID: https://orcid.org/0000-0002-0358-5249)
- Stefanie Quach (ORCID: https://orcid.org/0000-0003-2914-3649)
- Niklas Thon (ORCID: https://orcid.org/0000-0003-0011-5281)
- Jonas Reis (ORCID: https://orcid.org/0000-0001-8932-2265)
- Veit Stöcklein
- Katharina Müller (ORCID: https://orcid.org/0000-0001-7098-4744)
- Kim-Fabienne Degmayr
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1093/noajnl/vdaf234
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00