Lantaeuphanosides A–E from the leaves of Vietnamese <i>Lantana camara</i> Linn. and their anti-inflammatory effects on RAW264.7 macrophages

Five new euphane-type triterpenoid glucosides namely lantaeuphanosides A-E (<b>1</b>-<b>5</b>) along with homoplantaginin (<b>6</b>), 6-<i>O</i>-methyl-scutellarin (<b>7</b>), and isoverbascoside (<b>8</b>) were isolated from the methanol extract of the leaves of <i>Lantana camara</i> Linn. Their structures were elucidated by HRESI-MS, 1D, and 2D NMR data analysis. The inhibitory effects of <b>1</b>-<b>5</b> on nitric oxide production induced by lipopolysaccharide in RAW264.7 cells were evaluated. Moderate inhibition was found for lantaeuphanosides D (<b>4</b>) and E (<b>5</b>) with IC₅₀ values of 51.59 ± 5.68 and 29.19 ± 2.25 μM, respectively.