Thresholds adjustments and impact on clinical performance of three FIT assays in a colorectal cancer screening program
Threshold adjustment using a positivity rate harmonization strategy render differences in clinical performance statistically nonsignificant and leads to a stable colonoscopy rate between manufacturers. CRC screening programs should determine adjusted thresholds when changing FIT suppliers or when using multiple assays.
Authors
- Rosalie Plantefève
- Artuela Çaku (ORCID: https://orcid.org/0000-0002-9485-7245)
- François Corbin (ORCID: https://orcid.org/0000-0001-7712-5897)
- Luc Galarneau (ORCID: https://orcid.org/0000-0003-1871-9331)
- Charles Ménard (ORCID: https://orcid.org/0000-0001-9487-2499)
- Jean Y. Dubé (ORCID: https://orcid.org/0000-0003-1177-8013)
- Jean-Denis Rousseau
- Maude Bonin
Institutions
- Université de Sherbrooke (CA)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1515/cclm-2025-0546
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00