Pharmacogenetic Analysis of TPMT and NUDT15 in a European Pediatric Cohort with IBD and Autoimmune Diseases: Frequency Data and Clinical Relevance
Our results confirm the clinical relevance of <i>TPMT</i> and <i>NUDT15</i> genotyping to personalize thiopurine therapy in pediatric IBD. Routine implementation of rapid genetic testing, combined with therapeutic drug monitoring and a structured management algorithm, may optimize treatment outcomes and minimize preventable toxicity.
Authors
- Paola Montanari
- Cristina Calvi
- Alice Ponte (ORCID: https://orcid.org/0009-0004-7875-4299)
- Pier Luigi Calvo (ORCID: https://orcid.org/0000-0001-9264-3465)
- Massimiliano Bergallo (ORCID: https://orcid.org/0000-0002-9291-1332)
- Antonio Pizzol (ORCID: https://orcid.org/0000-0001-9679-0462)
- Stefano Gambarino
- Maddalena Dini
- Ilaria Galliano (ORCID: https://orcid.org/0000-0002-1273-3178)
- Anna Clemente
- Anna Pau (ORCID: https://orcid.org/0009-0002-5430-6008)
Institutions
- Ospedale Regina Margherita (IT)
- University of Turin (IT)
Publication Details
- Journal
- Genes
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3390/genes16111372
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National University of Defense Technology