Protocatechuic aldehyde ameliorates high glucose-induced podocyte injury by attenuating inflammation, oxidative stress, and apoptosis via suppression of endoplasmic reticulum stress through the GSK3β/Nrf2 pathway
PCA attenuates high glucose-induced podocyte injury, characterized by inflammation, oxidative stress, and apoptosis, suggesting that this protection involves inhibition of ER stress <i>via</i> activation of the GSK3β/Nrf2 signaling pathway.
Authors
- Li Yang (ORCID: https://orcid.org/0000-0002-2156-4564)
- Haifeng Wang (ORCID: https://orcid.org/0000-0003-4229-3668)
- Yishu Wang (ORCID: https://orcid.org/0000-0002-5352-6239)
Institutions
- China-Japan Friendship Hospital (CN)
- Tang Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fcell.2025.1693955
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00