Variant in a Taste Receptor Locus Tied to Changes in the Use of Insomnia Medication
Our findings indicate that carriers of the rs6488335-G variant, particularly homozygous women, were more likely to switch from zopiclone to zolpidem, potentially due to heightened sensitivity to taste-related side effects. Preemptive genetic testing could guide clinicians in prescribing zolpidem over zopiclone for individuals at risk, thereby reducing health care visits and improving treatment adherence.
Authors
- Þórarinn Gíslason (ORCID: https://orcid.org/0000-0002-6773-9876)
- Gísli H. Halldórsson (ORCID: https://orcid.org/0000-0001-7067-9862)
- Hreinn Stefánsson (ORCID: https://orcid.org/0000-0002-9331-6666)
- Guðrún A. Jónsdóttir
- G. Bragi Walters (ORCID: https://orcid.org/0000-0002-5415-6487)
- Saedís Saevarsdóttir (ORCID: https://orcid.org/0000-0001-9392-6184)
- Hafsteinn Einarsson (ORCID: https://orcid.org/0000-0001-5072-3678)
- Hannes Helgason
- Thorgeir E. Thorgeirsson (ORCID: https://orcid.org/0000-0002-5149-7040)
- Daníel F. Guðbjartsson (ORCID: https://orcid.org/0000-0002-5222-9857)
- Auðunn Skúta Snæbjarnarson (ORCID: https://orcid.org/0000-0002-3496-2991)
- Gyða Björnsdóttir (ORCID: https://orcid.org/0000-0002-8100-0306)
- Ingileif Jónsdóttir (ORCID: https://orcid.org/0000-0001-8339-150X)
- Hildur M. Aegisdottir (ORCID: https://orcid.org/0000-0003-0909-5942)
- Magnús K. Magnússon (ORCID: https://orcid.org/0000-0001-8593-4934)
- Rósa S. Gísladóttir (ORCID: https://orcid.org/0000-0003-0941-1888)
- Ástrós Skúladóttir (ORCID: https://orcid.org/0000-0002-5048-0933)
- Guðmundur Einarsson (ORCID: https://orcid.org/0000-0002-1326-2339)
- Garðar Sveinbjörnsson (ORCID: https://orcid.org/0000-0003-2429-9468)
- Kari Stefansson
- Vinicius Tragante
- Patrick Sulem
- Gudmar Thorleifsson
- Hannes K. Arnason
Institutions
- Reykjavík University (IS)
- deCODE Genetics (Iceland) (IS)
- University of Iceland (IS)
- Norwegian University of Science and Technology (NO)
- National University Hospital of Iceland (IS)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100652
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00