Liver biopsy quality criteria to exclude cirrhosis in case of suspicion of porto-sinusoidal vascular disorder
This study shows that, for the diagnosis of porto-sinusoidal vascular disorder, the minimum length of liver biopsy to exclude cirrhosis is 15 mm, with a minimum fragment of 10 mm. Picrosirius red had a slightly better performance than Masson's trichrome staining. Future guidelines might consider that a ≥15-mm-long biopsy, with a fragment ≥10 mm, is sufficient to rule out cirrhosis in case of suspicion of porto-sinusoidal vascular disorder with signs of portal hypertension.
Authors
- Juan Carlos García‐Pagán (ORCID: https://orcid.org/0000-0001-9032-4954)
- Aurélie Plessier (ORCID: https://orcid.org/0000-0001-5656-1622)
- François Durand (ORCID: https://orcid.org/0000-0002-0357-1090)
- Audrey Payancé (ORCID: https://orcid.org/0000-0001-7978-7982)
- Chloé De Broucker (ORCID: https://orcid.org/0000-0001-8397-0819)
- Pierre‐Emmanuel Rautou (ORCID: https://orcid.org/0000-0001-9567-1859)
- Valérie Paradis (ORCID: https://orcid.org/0000-0003-3142-3762)
- Sophie Hillaire (ORCID: https://orcid.org/0009-0009-9164-957X)
- PALWASHA ZAFAR
- María Luisa Botero
- Miguel Albuquerque (ORCID: https://orcid.org/0000-0001-7311-1623)
- Laure Elkrief
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Hôpital Beaujon (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Agència de Gestió d'Ajuts Universitaris i de Recerca (ES)
- Eticas Research & Consulting (Spain) (ES)
- Centre de Recherche sur l'Inflammation (FR)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- ABS Consulting (United States) (US)
- Hôpital Foch (FR)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101670
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00