Leonurine improves manifestation of chronic obstructive pulmonary disease in rats by inhibiting NF-κB and JAK2/STAT3 signaling pathways
Our results suggest that Leo exerts therapeutic effect against COPD. Leo inhibited tissue inflammation and oxidative stress in COPD rat models <i>via</i> inhibition of the NF-κB and JAK2/STAT3 signaling pathways.
Authors
- Ming-wei Hao
- Qiangqiang Chu
- Peng Song (ORCID: https://orcid.org/0000-0002-1748-5580)
- Huadong Meng (ORCID: https://orcid.org/0000-0001-7422-9535)
- Yanbei Zhang (ORCID: https://orcid.org/0000-0002-1035-3681)
- Yangyang Sun (ORCID: https://orcid.org/0009-0002-4808-2925)
Institutions
- Bengbu Medical College (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/08923973.2025.2586126
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00