Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy

Photosensitizing systems based on methylene blue (MB)-loaded calcium alginate (CaA) and alginic acid (AA) aerogels were developed for photodynamic therapy of difficult-to-heal wounds. Hybrid aerogels incorporating polyvinylpyrrolidone (PVP, 2.5-40 wt%) into CaA and AA matrices were also made. The MB release kinetics in a phosphate buffer were found to depend on the aerogel type (AA or CaA). The incorporation of PVP increased the MB release rate by 1.5-2 times. The singlet oxygen (<sup>1</sup>O<sub>2</sub>) generation efficiency of MB embedded in the aerogels was influenced by their porosity and chemical composition. The activity of MB in the photogeneration of <sup>1</sup>O<sub>2</sub> increased by up to four times in the PVP-containing aerogels. Furthermore, the photoactivity of MB in the hybrid aerogel matrices significantly exceeded that in the single-component alginate aerogels.

Authors

Institutions

Publication Details

Journal
Frontiers in Chemistry
Published
2025-11-11
DOI
https://doi.org/10.3389/fchem.2025.1702876
Primary Topic
Photodynamic Therapy Research Studies
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy

Ru‐Lin Huang, V. P. Shantarovich, Н. А. Аксенова, I. V. Shershnev et al.
Frontiers in Chemistry
Photodynamic Therapy Research Studies
article

Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy

Ru‐Lin Huang, V. P. Shantarovich, Н. А. Аксенова, I. V. Shershnev, А. С. Копылов, Polina Bikmulina, V. G. Bekeshev, Qingfeng Li, Anastasiya Kuryanova, Anastasiya Cherkasova, Peter S. Timashev, А. А. Акованцева, Vladislav Kaplin, Victoriya Timofeeva, Anna Solovieva, Tatyana S. Zarkhina, Sergey Rachev
article en

Abstract

Photosensitizing systems based on methylene blue (MB)-loaded calcium alginate (CaA) and alginic acid (AA) aerogels were developed for photodynamic therapy of difficult-to-heal wounds. Hybrid aerogels incorporating polyvinylpyrrolidone (PVP, 2.5-40 wt%) into CaA and AA matrices were also made. The MB release kinetics in a phosphate buffer were found to depend on the aerogel type (AA or CaA). The incorporation of PVP increased the MB release rate by 1.5-2 times. The singlet oxygen (<sup>1</sup>O<sub>2</sub>) generation efficiency of MB embedded in the aerogels was influenced by their porosity and chemical composition. The activity of MB in the photogeneration of <sup>1</sup>O<sub>2</sub> increased by up to four times in the PVP-containing aerogels. Furthermore, the photoactivity of MB in the hybrid aerogel matrices significantly exceeded that in the single-component alginate aerogels.

Frontiers in ChemistryVol. 13
Sechenov University (RU), Shanghai Jiao Tong University (CN), Moscow State University of Fine Chemical Technologies (RU), Semenov Institute of Chemical Physics (RU), Shanghai Ninth People's Hospital (CN)
Russian Science Foundation
Openalex Percentile: Top 52%
Photodynamic Therapy Research Studies
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.