A TBC1D9-Rab29 axis controls homeostatic NF-κB signaling and selective IL-6 production in epithelial cells
The TBC1D9-Rab29 axis connects GTPase signaling and membrane trafficking to specifically regulate IL-6 in epithelial cells, revealing a non-traditional mechanism for modulating inflammation and a potential target in IL-6-driven diseases.
Authors
- Ichirô Nakagawa (ORCID: https://orcid.org/0000-0001-6552-1702)
- Atsuko Minowa‐Nozawa
- Kazunori Murase (ORCID: https://orcid.org/0000-0002-7202-4357)
- Takashi Nozawa (ORCID: https://orcid.org/0000-0002-1822-5553)
- Xin Hu (ORCID: https://orcid.org/0000-0002-8915-3526)
Institutions
- Kyoto University (JP)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fcimb.2025.1688013
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- China Scholarship Council
- University of Tokyo
- Daiichi Sankyo Foundation of Life Science
- Senri Life Science Foundation
- Daiichi Sankyo Europe