Statin use and the risk of tubulointerstitial nephritis: a real-world signal detection analysis using FDA Adverse Event Reporting System
This real-world analysis identifies a statistically significant disproportionality signal that indicates a possible association between statin use and TIN, particularly in older adults. Clinicians may consider TIN in patients presenting with unexplained renal dysfunction while on statins. Further research is warranted to evaluate this association and identify patient-level risk factors.
Authors
- Amani Khardali (ORCID: https://orcid.org/0000-0002-5611-4782)
- Ayesha Yasmeen (ORCID: https://orcid.org/0000-0002-2954-5413)
- Thamir M. Alshammari (ORCID: https://orcid.org/0000-0002-5630-2468)
- Hadi A. Almansour (ORCID: https://orcid.org/0000-0002-5866-8404)
- Mamoon H. Syed (ORCID: https://orcid.org/0000-0001-6627-7895)
Institutions
- Jazan University (SA)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fmed.2025.1674331
- Citations
- 1
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 1.36