Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer’s disease
Prolonged MFB-ICSS treatment mitigates cognitive deficits, modulates circulating levels of miRNA-495 and miR-146a, restores hippocampal NRF2 levels, and preserves corpus callosum integrity in the SAD rat model by STZ injection. These findings highlight the therapeutic potential of MFB-ICSS as a non-pharmacological intervention in AD. Furthermore, this study confirms NRF2 as a target of miR-495 in the context of AD.
Authors
- Laura Aldavert-Vera (ORCID: https://orcid.org/0000-0002-1506-4790)
- Laia Vila-Solés
- Gemma Carreras‐Badosa (ORCID: https://orcid.org/0000-0003-2100-0221)
- Pilar Segura-Torres (ORCID: https://orcid.org/0000-0001-6963-8625)
- Elisabet Kádár (ORCID: https://orcid.org/0000-0001-9135-4637)
- Soleil García‐Brito (ORCID: https://orcid.org/0000-0002-4292-3212)
- Gemma Huguet (ORCID: https://orcid.org/0000-0002-1439-5053)
- Andrea Riberas‐Sánchez (ORCID: https://orcid.org/0000-0002-1980-5250)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat de Girona (ES)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fnagi.2025.1671196
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitat de Girona
- Ministerio de Ciencia e Innovación