Severe mitral valve papillary muscle rupture of isolated Whipple's endocarditis: a case report and review of the literature
We present the first case of isolated TWE in a young Asian female, notable for its atypical clinical presentation, fulminant progression, and profound diagnostic challenges. Clinicians should maintain a high vigilance for blood culture-negative endocarditis. Timely diagnosis and appropriate treatment are crucial for improving prognosis. mNGS analysis of samples from suspected disseminated sites may yield crucial diagnostic breakthrough.
Authors
- Wanglin Liu (ORCID: https://orcid.org/0000-0002-1090-8325)
- Na Wang (ORCID: https://orcid.org/0000-0002-3760-5420)
- Xinxin Mao (ORCID: https://orcid.org/0000-0002-2938-1025)
- Liangyu Mi (ORCID: https://orcid.org/0009-0004-3958-897X)
- Yan Shi (ORCID: https://orcid.org/0000-0001-7769-8644)
- Xinchen Wang (ORCID: https://orcid.org/0000-0002-6169-665X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fcvm.2025.1669997
- Primary Topic
- Whipple's Disease and Interleukins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking Union Medical College Hospital
- Peking Union Medical College