Clinical features and oncologic outcomes of primary retroperitoneal ganglioneuroma: a retrospective cohort study of 51 patients from a high-volume sarcoma center

Retroperitoneal ganglioneuroma (RGN) is a rare benign tumor that frequently presents with nonspecific symptoms. While surgical resection remains the cornerstone of management, it is best undertaken at specialized, high-volume sarcoma centers to mitigate operative risks. When complete excision is precluded by critical vascular involvement, subtotal resection represents a judicious alternative. For selected patients with small, asymptomatic tumors-particularly those with elevated surgical risk-active surveillance is a reasonable option. Despite a generally favorable prognosis, long-term follow-up is recommended.