Clinical characteristics of Treponema denticola-associated lung abscess diagnosed by metagenomic next-generation sequencing: a case series analysis
<i>T. denticola</i> lung abscess is most commonly seen in individuals with poor oral hygiene. It presents as an indolent, chronic course and a high incidence of hemoptysis. Typical CT findings include a mass-like lesion with cavitation but no air-fluid level. Traditional microbiological detection often yield false negative results, making mNGS a critical diagnostic tool. First-line therapy should include β-lactams or tetracyclines, and surgery is warranted for refractory cases or massive hemoptysis.
Authors
- Hangdi Xu (ORCID: https://orcid.org/0000-0001-7468-2014)
- Ying Fu (ORCID: https://orcid.org/0000-0003-1177-0871)
- Bo Liao
- Pengpeng Zhou (ORCID: https://orcid.org/0000-0002-5359-1540)
- Ran Tao (ORCID: https://orcid.org/0000-0003-2064-7429)
- Jing Gu (ORCID: https://orcid.org/0000-0002-7904-2793)
- Shengjun Wu (ORCID: https://orcid.org/0000-0002-1394-2270)
- Yueqing Xu
- Xiaoling Wang (ORCID: https://orcid.org/0000-0003-1659-466X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Xinjiang Production and Construction Corps (CN)
- Sir Run Run Shaw Hospital (CN)
- General Hospital of Guangzhou Military Command (CN)
- Zhejiang Medicine (China) (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.3389/fcimb.2025.1688498
- Primary Topic
- Otolaryngology and Infectious Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health Commission of the People's Republic of China