A systematic study of molecular diagnosis, treatment, and prognosis in infant-type hemispheric glioma: An individual patient data meta-analysis of 164 patients

Together, these findings show that IHG is a fusion driven tumor of the very young that is survivable even after progression. While optimal primary therapy for patients with IHG has yet to be established, the findings of this meta-analysis suggest treatment should focus on lowering surgical morbidity and improving its success.

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Publication Details

Journal
Neuro-Oncology
Published
2025-11-06
DOI
https://doi.org/10.1093/neuonc/noaf264
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

A systematic study of molecular diagnosis, treatment, and prognosis in infant-type hemispheric glioma: An individual patient data meta-analysis of 164 patients

Gerrit H. Gielen, L. I. Papusha, Angela Mastronuzzi, André O. von Bueren et al.
Neuro-Oncology
Glioma Diagnosis and Treatment
article

A systematic study of molecular diagnosis, treatment, and prognosis in infant-type hemispheric glioma: An individual patient data meta-analysis of 164 patients

Gerrit H. Gielen, L. I. Papusha, Angela Mastronuzzi, André O. von Bueren, Martin Benesch, Christof M. Kramm, Scott Ryall, Maria Vinci, Uri Tabori, Andreas Waha, Ana Guerreiro Stücklin, Darren Hargrave, Hamza Gorsi, Paul Klimo, Dominik Sturm, Ahmed Gilani, Moatasem El‐Ayadi, Christian Hagel, Álvaro Lassaletta, Chris Jones, Bruna Minniti Mançano, Rui Manuel Reis, Jason Chiang, Dannis G. van Vuurden, Amar Gajjar, Fabienne Toutain, Stefan M. Pfister, Torsten Pietsch, Thomas Perwein, Lara Chavaz, Congyu Lu, Giles W Robinson, Veronica Biassoni, Sophie E. M. Veldhuijzen van Zanten, Matthew Clarke, Simon Bailey, Sandeep Kumar Dhanda, Michael Karremann, Cynthia Hawkins, Alan Mackay, Gunther Nussbaumer, Maura Massimino, Nicolas Silvestrini, David Jones, Andrés Morales La Madrid, Xin Zhou, Aditi Bagchi
article en

Abstract

Together, these findings show that IHG is a fusion driven tumor of the very young that is survivable even after progression. While optimal primary therapy for patients with IHG has yet to be established, the findings of this meta-analysis suggest treatment should focus on lowering surgical morbidity and improving its success.

Neuro-Oncology
University of Geneva (CH), Hospital Sant Joan de Déu Barcelona (ES), St. Jude Children's Research Hospital (US), Institute of Cancer Research (GB), Universität Hamburg (DE), University of Tennessee Health Science Center (US), Central Michigan University (US), Medical University of Graz (AT), Heidelberg University (DE), Great Ormond Street Hospital (GB), Royal Victoria Infirmary (GB), Hospital for Sick Children (CA), Erasmus MC (NL), University Hospital Heidelberg (DE), Hospital de Câncer de Barretos (BR), Children's Hospital Colorado (US), Brain Tumour Research (GB), University Hospital of Geneva (CH), University Medical Center Hamburg-Eppendorf (DE), National Center for Tumor Diseases (DE), Hospital Infantil Universitario Niño Jesús (ES), Universitätsmedizin Göttingen (DE), Hopp Children's Cancer Center Heidelberg (DE), Bambino Gesù Children's Hospital (IT), Princess Máxima Center (NL), Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology (RU), University Children's Hospital Zurich (CH), Children's Hospital of Michigan (US), University Medical Centre Mannheim (DE), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), Le Bonheur Children's Hospital (US), Children Cancer Hospital (EG), Life & Brain (Germany) (DE), University College London (GB), Geneva College (US), University of Göttingen (DE), Erasmus University Rotterdam (NL), University of Colorado Denver (US), University of Minho (PT)
Openalex Percentile: Top 53%
Glioma Diagnosis and Treatment
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