Single-nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a Phase 0/1 trial of recurrent high-grade glioma
This trial underscores the value of integrating pharmacokinetics, pharmacodynamics, and single nucleus transcriptomics in Phase 0/1 surgical studies to assess treatment effects, including malignant cell state shifts. ClinicalTrials.gov identifier: NCT03834740.
Authors
- Yoko Fujita (ORCID: https://orcid.org/0000-0002-2411-5473)
- James McNamara
- Chelsea Montgomery
- Elise T. Courtois (ORCID: https://orcid.org/0000-0002-8749-2719)
- Avishay Spitzer (ORCID: https://orcid.org/0000-0001-6551-9338)
- Yoshie Umemura (ORCID: https://orcid.org/0000-0001-7137-661X)
- Nader Sanai (ORCID: https://orcid.org/0000-0002-5581-0516)
- Roel G.W. Verhaak (ORCID: https://orcid.org/0000-0003-2773-0436)
- Shwetal Mehta
- Anita DeSantis
- Kevin C. Johnson (ORCID: https://orcid.org/0000-0003-0016-5158)
- William F. Flynn (ORCID: https://orcid.org/0000-0001-6533-0340)
- Amy Hong
- Artak Tovmasyan (ORCID: https://orcid.org/0000-0002-8612-1676)
- An‐Chi Tien (ORCID: https://orcid.org/0000-0002-4406-4044)
- Jocelyn Harmon (ORCID: https://orcid.org/0009-0000-5684-1907)
- Leonel Elena-Sanchez
- Jing Li (ORCID: https://orcid.org/0000-0003-2065-9040)
- Seongho Kim (ORCID: https://orcid.org/0000-0003-1120-073X)
- Jun Jiang (ORCID: https://orcid.org/0000-0001-9590-9951)
- Yu‐Wei Chang (ORCID: https://orcid.org/0000-0003-3333-5424)
- Paul Gabriel
Institutions
- Yale New Haven Hospital (US)
- Barrow Neurological Institute (US)
- Tel Aviv University (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Yale University (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- American Committee for the Weizmann Institute of Science (US)
- Jackson Laboratory (US)
- Yale New Haven Health System (US)
- Weizmann Institute of Science (IL)
- UConn Health (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/neuonc/noaf257
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25