Single-nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a Phase 0/1 trial of recurrent high-grade glioma

This trial underscores the value of integrating pharmacokinetics, pharmacodynamics, and single nucleus transcriptomics in Phase 0/1 surgical studies to assess treatment effects, including malignant cell state shifts. ClinicalTrials.gov identifier: NCT03834740.

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Publication Details

Journal
Neuro-Oncology
Published
2025-11-06
DOI
https://doi.org/10.1093/neuonc/noaf257
Citations
2
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
3.25
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article

Single-nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a Phase 0/1 trial of recurrent high-grade glioma

Yoko Fujita, James McNamara, Chelsea Montgomery, Elise T. Courtois et al.
2 citations
Neuro-Oncology
Glioma Diagnosis and Treatment
3.25
article

Single-nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a Phase 0/1 trial of recurrent high-grade glioma

Yoko Fujita, James McNamara, Chelsea Montgomery, Elise T. Courtois, Avishay Spitzer, Yoshie Umemura, Nader Sanai, Roel G.W. Verhaak, Shwetal Mehta, Anita DeSantis, Kevin C. Johnson, William F. Flynn, Amy Hong, Artak Tovmasyan, An‐Chi Tien, Jocelyn Harmon, Leonel Elena-Sanchez, Jing Li, Seongho Kim, Jun Jiang, Yu‐Wei Chang, Paul Gabriel
article en
2 citations

Abstract

This trial underscores the value of integrating pharmacokinetics, pharmacodynamics, and single nucleus transcriptomics in Phase 0/1 surgical studies to assess treatment effects, including malignant cell state shifts. ClinicalTrials.gov identifier: NCT03834740.

Neuro-Oncology
Yale New Haven Hospital (US), Barrow Neurological Institute (US), Tel Aviv University (IL), Tel Aviv Sourasky Medical Center (IL), Yale University (US), The Barbara Ann Karmanos Cancer Institute (US), American Committee for the Weizmann Institute of Science (US), Jackson Laboratory (US), Yale New Haven Health System (US), Weizmann Institute of Science (IL), UConn Health (US)
Openalex Percentile: Top 7%
Glioma Diagnosis and Treatment
3.25
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