Assessment of molecular tools in pediatric, adolescent, and young adult meningioma highlights the need for lifespan precision in neuro-oncology
Molecular tools developed in adult-dominant cohorts do not generalize to younger patients due to both biological divergence and exclusion from model development. These findings underscore the need for age-specific molecular frameworks and highlight the imperative of including P/AYA populations in precision neuro-oncology research to ensure lifespan-equitable care.
Authors
- Jeff Liu (ORCID: https://orcid.org/0000-0002-9928-7552)
- Farshad Nassiri (ORCID: https://orcid.org/0000-0002-0797-3425)
- Kenneth Aldape
- Aaron Cohen‐Gadol (ORCID: https://orcid.org/0000-0002-4946-1524)
- Marcos Tatagiba
- Olivia Singh
- Severa Bunda
- Felix Behling (ORCID: https://orcid.org/0000-0002-1083-1276)
- Chloe Gui (ORCID: https://orcid.org/0000-0002-6685-1970)
- Silky Chotai (ORCID: https://orcid.org/0000-0001-5981-3231)
- Leeor Yefet
- Derek S. Tsang (ORCID: https://orcid.org/0000-0002-9762-6901)
- Jill S. Barnholtz‐Sloan (ORCID: https://orcid.org/0000-0001-6190-9304)
- Alireza Mansouri (ORCID: https://orcid.org/0000-0002-7442-7539)
- Serge Makarenko (ORCID: https://orcid.org/0000-0002-6283-249X)
- Andrew Ajisebutu
- Justin Z. Wang (ORCID: https://orcid.org/0000-0001-8998-7443)
- Sameer Agnihotri (ORCID: https://orcid.org/0000-0001-6584-3795)
- Yasin Mamatjan (ORCID: https://orcid.org/0000-0002-8807-2927)
- Yosef Ellenbogen (ORCID: https://orcid.org/0000-0003-1390-1361)
- Ramneet Kaloti
- Gelareh Mohammed Zadeh (ORCID: https://orcid.org/0000-0002-6637-4502)
- Qingxia Wei (ORCID: https://orcid.org/0000-0002-7723-6180)
- Lola B. Chambless (ORCID: https://orcid.org/0000-0001-5864-5387)
- Andrew Edward Sloan (ORCID: https://orcid.org/0000-0001-9607-5063)
- Sheila Mansouri (ORCID: https://orcid.org/0000-0002-7255-207X)
- Ghazaleh Tabatabai (ORCID: https://orcid.org/0000-0002-3542-8782)
- Andrew Gao (ORCID: https://orcid.org/0000-0002-2204-3277)
- Alexander Landry (ORCID: https://orcid.org/0000-0002-7250-8466)
- Vikas Patil (ORCID: https://orcid.org/0000-0001-9564-4420)
- Stephen Yip
- Rebecca Yakubov
- Phooja Persaud
Institutions
- University Health Network (CA)
- Mayo Clinic (US)
- University of British Columbia (CA)
- Thompson Rivers University (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Keck Hospital of USC (US)
- Princess Margaret Cancer Centre (CA)
- Piedmont Cancer Institute (US)
- National Cancer Institute (UA)
- University Children's Hospital Tübingen (DE)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- National Cancer Institute (US)
- Hertie Institute for Clinical Brain Research (DE)
- Mayo Clinic in Florida (US)
- Center for Cancer Research (US)
- Neurological Surgery (US)
- Division of Cancer Epidemiology and Genetics
- University of Tübingen (DE)
- Penn State Milton S. Hershey Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1093/neuonc/noaf252
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 0.00