MTHFD2 orchestrates monocyte–macrophage immune homeostasis by targeting Rap1 to protect against CVB3-induced viral myocarditis
We identified MTHFD2 as an immune regulator of monocyte-macrophage homeostasis to protect against CVB3-induced VMC. Targeted regulation of MTHFD2 is a potential therapeutic option for VMC clinically.
Authors
- Shuai Fu (ORCID: https://orcid.org/0000-0002-4192-5259)
- Wei‐Dong Yu
- Xiaoping Leng (ORCID: https://orcid.org/0000-0001-8883-8884)
- Yi Li (ORCID: https://orcid.org/0000-0001-8661-4617)
- Fei Gao (ORCID: https://orcid.org/0000-0001-7389-1973)
- Jiawei Tian
- Guiming Sun
- Guoxia Shi (ORCID: https://orcid.org/0009-0003-8464-2659)
- Xiangli Xu
- Danxiang Feng
- Pingping Wan
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang Provincial Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Education Department of Heilongjiang Province (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/cvr/cvaf227
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39