The association between dietary quercetin intake and risk of depressive symptoms: the TCLSIH cohort study
Recent evidence suggests that dietary polyphenols may be linked to positive effects on brain health. This study aimed to examine the association between the quercetin intake and depressive symptoms. A total of 7766 participants without baseline depressive symptoms were included. Dietary quercetin intake was assessed using a validated food frequency questionnaire, and depressive symptoms were assessed by the Self-Rating Depression Scale score. Multivariable Cox proportional hazards models were used to determine the association. After multivariate adjustment, as quartiles of quercetin intake increased, HRs (95% CIs) for depressive symptoms were 1.00 (reference value), 0.72 (0.56, 0.93), 0.69 (0.53, 0.90), and 0.63 (0.46, 0.85) in females (<i>p</i> for trend=0.0026) and 1.00 (reference), 0.94 (0.75, 1.17), 0.84 (0.66, 1.06), and 0.92 (0.71, 1.20) in males (<i>p</i> for trend=0.35), respectively. Our study revealed that dietary quercetin intake may reduce the risk of depressive symptoms in female, but not in males.
Authors
- Qing Zhang (ORCID: https://orcid.org/0000-0002-5652-4036)
- Kaijun Niu (ORCID: https://orcid.org/0000-0002-8772-2481)
- Niuniu Sun (ORCID: https://orcid.org/0000-0002-9865-2511)
- Jie Yu (ORCID: https://orcid.org/0000-0002-1168-8766)
- Dandan Zhu (ORCID: https://orcid.org/0000-0001-6992-2714)
- Ming‐Lung Yu (ORCID: https://orcid.org/0000-0001-8145-1900)
- Xuehui Wu (ORCID: https://orcid.org/0000-0002-3911-5994)
- Lirui Jiao (ORCID: https://orcid.org/0000-0002-2505-7447)
- Xing Wang (ORCID: https://orcid.org/0000-0003-4313-6381)
- Hongmei Wu (ORCID: https://orcid.org/0000-0002-1402-4359)
- Di Wang (ORCID: https://orcid.org/0009-0006-3620-7857)
- Jinjin Zhang (ORCID: https://orcid.org/0000-0002-5557-3637)
- Ge Meng (ORCID: https://orcid.org/0000-0002-7205-5532)
- Kun Song (ORCID: https://orcid.org/0000-0002-1564-9916)
- Yunliang Zheng
- Yinxiao Chen
- Yaxiao Wang
- Hao Yu (ORCID: https://orcid.org/0009-0006-4768-0025)
- Hong Chang (ORCID: https://orcid.org/0000-0001-7478-917X)
- Shaomei Sun (ORCID: https://orcid.org/0000-0002-6567-4845)
- Qiyu Jia (ORCID: https://orcid.org/0000-0002-8094-142X)
- Dongli Wang
- Yeqing Gu
- Haoran Geng (ORCID: https://orcid.org/0000-0001-5115-4446)
- P. C. Y. Tong
- Liyuan Fu (ORCID: https://orcid.org/0000-0002-3189-8656)
- Li Liu (ORCID: https://orcid.org/0000-0002-0504-418X)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin University of Technology (CN)
- Henan University of Science and Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Medical University General Hospital (CN)
- Henan University of Technology (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- International Journal of Food Sciences and Nutrition
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1080/09637486.2025.2582562
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 0.00