CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host–pathogen interactions
CD-CODE 2.0 (https://cd-code.org) is an enhanced web application and database of condensates, expanding the utility of version 1.0 for biomedical research. New features include data on nucleic acids condensate components, infectious condensates, condensate modulating drugs, and disease-linked condensates. Enhanced search functions, programmatic access, and relational architecture enable interconnectivity across major biomedical databases (e.g. condensates, proteins, chemistry, and disease), fostering systems-level insights and accelerating hypothesis generation and therapeutic discovery through the lens of condensate biology.
Authors
- Chi Fung Willis Chow (ORCID: https://orcid.org/0000-0001-9889-9664)
- Soumyadeep Ghosh (ORCID: https://orcid.org/0000-0002-4691-3636)
- Anna Hadarovich (ORCID: https://orcid.org/0000-0002-5139-4308)
- HongKee Moon (ORCID: https://orcid.org/0000-0001-7159-924X)
- Silja Zedlitz (ORCID: https://orcid.org/0000-0002-7584-2099)
- David Kuster (ORCID: https://orcid.org/0000-0002-8157-9223)
- Anthony A. Hyman (ORCID: https://orcid.org/0000-0003-0851-704X)
- Carsten Hoege
- Natasha Lewis
- Allysa P. Kemraj (ORCID: https://orcid.org/0000-0002-3722-9074)
- Diego A. Vargas (ORCID: https://orcid.org/0000-0003-2627-2066)
- Jonathan C. Savage
- Lena Hersemann (ORCID: https://orcid.org/0000-0001-9268-2915)
- Hari Singh (ORCID: https://orcid.org/0000-0002-4063-9533)
- Maxim Scheremetjew (ORCID: https://orcid.org/0000-0002-7458-3072)
- Jik Nijssen (ORCID: https://orcid.org/0000-0003-0013-9750)
- Diana M. Mitrea (ORCID: https://orcid.org/0000-0003-4501-0846)
- Alberto Hernandez-Armendariz (ORCID: https://orcid.org/0000-0001-6392-5762)
- Ágnes Tóth-Petróczy (ORCID: https://orcid.org/0000-0002-0333-604X)
- Wei Yu (ORCID: https://orcid.org/0000-0002-1777-5254)
- Jialin Yin
- Ksenia Kuznetsova (ORCID: https://orcid.org/0000-0001-6877-1643)
Institutions
- SUNY Upstate Medical University (US)
- Max Planck Institute for Medical Research (DE)
- Center for Systems Biology Dresden (DE)
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- Technische Universität Dresden (DE)
- Viewpoints Research Institute (US)
Publication Details
- Journal
- Nucleic Acids Research
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1093/nar/gkaf1104
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50