The validation of histological criteria from the IAIH‐PG to distinguish AIH from drug‐induced liver injury
The new histological criteria exhibit good diagnostic efficacy in distinguishing AIH from DILI in China, with high AUROC. Key discriminators include low aminotransferase, ANA ≥1:160, lobular lymphoplasmacytic infiltrate and more than mild inflammation, which may further improve diagnostic accuracy for AIH.
Authors
- Xuchen Zhang (ORCID: https://orcid.org/0000-0002-1484-4672)
- Jimin Liu (ORCID: https://orcid.org/0000-0003-1145-3999)
- Zongming Chen (ORCID: https://orcid.org/0000-0002-8328-9350)
- Xinyan Zhao (ORCID: https://orcid.org/0000-0002-8016-4368)
- Gwyneth Shook Ting Soon (ORCID: https://orcid.org/0000-0001-5318-9327)
- Romil Saxena (ORCID: https://orcid.org/0000-0002-1872-0431)
- Hanlin Wang
- Mina Komuta (ORCID: https://orcid.org/0000-0002-3999-1417)
- Li Wang (ORCID: https://orcid.org/0009-0000-1070-742X)
- Zikun Ma (ORCID: https://orcid.org/0009-0002-2446-665X)
- Mukul Vij (ORCID: https://orcid.org/0000-0003-0149-0294)
- Bin Wang (ORCID: https://orcid.org/0000-0003-4504-3752)
- Min� Li (ORCID: https://orcid.org/0000-0002-1163-8961)
- Yongfeng Yang (ORCID: https://orcid.org/0000-0002-3214-0038)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-3193-2655)
- Jiping Zhang (ORCID: https://orcid.org/0009-0000-4878-4607)
Institutions
- Fujian Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Mayo Clinic (US)
- Emory University (US)
- University of California, Los Angeles (US)
- Capital Medical University (CN)
- Jinyintan Hospital (CN)
- Yale University (US)
- National Clinical Research Center for Digestive Diseases (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Mayo Clinic in Arizona (US)
- National University Hospital (SG)
- Mayo Clinic in Florida (US)
- Beijing Friendship Hospital (CN)
- National University Health System (SG)
- Hamilton Health Sciences (CA)
- International University of Health and Welfare (JP)
- Bharath University (IN)
- Guangzhou Medical University (CN)
- McMaster University (CA)
Publication Details
- Journal
- Histopathology
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1111/his.70027
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00