NDC80 promotes epithelial to mesenchymal transition of esophageal squamous cell carcinoma through macrophages polarization and PI3K/AKT pathway activation
Our findings established NDC80 as a master regulator of ESCC metastasis by activating TAM-mediated PI3K/AKT and promoting EMT. These insights positioned NDC80 as a promising therapeutic target, offering a potential strategy to prevent ESCC progression.
Authors
- Kuisheng Chen (ORCID: https://orcid.org/0000-0001-5097-2009)
- Yinghao Liang
- Jiao Shu
- Zhi Sun (ORCID: https://orcid.org/0000-0001-6007-4923)
- Chenbo Yang
- Yiwei Li (ORCID: https://orcid.org/0000-0003-2389-3203)
- Na Zhao (ORCID: https://orcid.org/0000-0003-3655-7145)
- Xiaonan Liu (ORCID: https://orcid.org/0000-0003-3661-7961)
- Miaomiao Sun (ORCID: https://orcid.org/0009-0008-5737-0519)
- Mohammad Tabish (ORCID: https://orcid.org/0000-0001-8950-3576)
Institutions
- Zhengzhou University (CN)
- The Central Hospital of Xiao gan (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s40001-025-03397-3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00