Intranasal vasopressin, but not oxytocin, decreases ethanol intake in socially housed mice
Our studies for the first time demonstrate that Oxt loses its effectiveness when administered to rodents in translationally relevant conditions (intranasal route and social housing), which could reflect its limited success in clinical trials. In addition, they suggest that intranasal AVP could be more effective than Oxt in decreasing alcohol intake in these conditions.
Authors
- Andrey E. Ryabinin (ORCID: https://orcid.org/0000-0003-4662-3775)
- Jonathan A. Zweig (ORCID: https://orcid.org/0000-0002-7015-9821)
- Kelly M. Abshire
- Michelle A. Nipper
- Michael Johnson (ORCID: https://orcid.org/0009-0008-1336-3827)
Institutions
- Oregon Health & Science University (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1007/s00213-025-06962-0
- Citations
- 1
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.44
Funders
- National Institutes of Health