Exosomal miR-132-3p derived from M1 macrophages mediates diffuse alveolar haemorrhage in systemic lupus erythematosus
M1 macrophage-originated exosomal miR-132-3p promotes lung injury in SLE-associated DAH by impairing alveolar barrier integrity and enhancing inflammatory signalling via the SIRT1/NF-κB axis. Targeting miR-132-3p could offer a novel treatment option for SLE-DAH.
Authors
- Qiongyan Li
- Fu-Ce Lu
- Chunfeng Liang
- Guanhua Qiu (ORCID: https://orcid.org/0000-0003-4994-7011)
- Xun Chen (ORCID: https://orcid.org/0000-0001-6937-755X)
- Jun Xie (ORCID: https://orcid.org/0000-0003-0074-2349)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1093/rheumatology/keaf600
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00