Hope for 17 patients with chronic cluster headache: efficacy evaluation of upper cervical spinal nerve root release surgery (2020–2023)

The findings from this case series suggest that upper cervical spinal nerve root release surgery is a safe and effective treatment for chronic cluster headache, offering substantial clinical improvements. However, due to the small sample size, further large-scale, placebo-controlled studies are essential to corroborate these results, validate the long-term efficacy and safety of the procedure, and accurately determine the contribution of the surgical intervention beyond the placebo effect.