Loss of FAM134B increased endoplasmic reticulum stress and induced cell autophagy in breast cancer

Downregulation of FAM134B inhibited the development of breast cancer through inducing apoptosis, autophagy, and ER stress of breast cancer cells.

Authors

Li Zhu (ORCID: https://orcid.org/0000-0002-9294-5727)
Zhibing Qiu (ORCID: https://orcid.org/0000-0001-8434-1176)
Deyue Liu (ORCID: https://orcid.org/0000-0001-5131-5668)
Wanqiu Huang (ORCID: https://orcid.org/0000-0003-3354-1148)
Zhaoqi Zhang (ORCID: https://orcid.org/0000-0002-8415-0019)
Yan Fang (ORCID: https://orcid.org/0000-0001-6814-2935)
Shuning Ding (ORCID: https://orcid.org/0000-0003-4938-5354)

Institutions

Shanghai Jiao Tong University (CN)
Shanghai Chest Hospital (CN)
Huashan Hospital (CN)

Publication Details

Journal: Frontiers in Immunology
Published: 2025-11-10
DOI: https://doi.org/10.3389/fimmu.2025.1652888
Primary Topic: Autophagy in Disease and Therapy
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China
Shanghai Jiao Tong University
Fundamental Research Funds for the Central Universities

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article

Loss of FAM134B increased endoplasmic reticulum stress and induced cell autophagy in breast cancer

Li Zhu, Zhibing Qiu, Deyue Liu, Wanqiu Huang et al.

Nov 10, 2025

Frontiers in Immunology

Autophagy in Disease and Therapy

article

Loss of FAM134B increased endoplasmic reticulum stress and induced cell autophagy in breast cancer

Li Zhu, Zhibing Qiu, Deyue Liu, Wanqiu Huang, Zhaoqi Zhang, Yan Fang, Shuning Ding

November 10, 2025article en

Abstract

Downregulation of FAM134B inhibited the development of breast cancer through inducing apoptosis, autophagy, and ER stress of breast cancer cells.

Frontiers in ImmunologyVol. 16

Shanghai Jiao Tong University (CN), Shanghai Chest Hospital (CN), Huashan Hospital (CN)

National Natural Science Foundation of China, Shanghai Jiao Tong University, Fundamental Research Funds for the Central Universities

Openalex Percentile: Top 56%

Autophagy in Disease and Therapy

DOI Open Access PDF OpenAlex

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Loss of FAM134B increased endoplasmic reticulum stress and induced cell autophagy in breast cancer — Li Zhu, Zhibing Qiu, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS