A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure
Together, our results demonstrated that NMEG-CGRP is a non-toxic, stable, and bioactive CGRP-analog, and protects against pressure-induced HF in mice. Thus, NMEG-CGRP is a promising novel CGRP-analog that may be used in the treatment of HF and potentially other cardiac diseases.
Authors
- Lester F. Williams
- Stephanie DeLoach
- Jay D. Potts (ORCID: https://orcid.org/0000-0003-4932-9643)
- Ambrish Kumar (ORCID: https://orcid.org/0000-0002-7576-561X)
- Donald J. DiPette (ORCID: https://orcid.org/0000-0002-5762-9104)
Institutions
- University of South Carolina (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fphar.2025.1692472
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of South Carolina
- Society for Community Research and Action