Pituitary hormone deficiencies in prolactinomas: prevalence, predictors, and functional recovery
Non-gonadal hypopituitarism is common in prolactinomas, especially larger tumors. Tumor size was the strongest predictor of both the presence and recovery of hormonal deficits, with an optimal cut-off of 17 mm. Long-term follow-up is essential, as many patients, especially those with smaller tumors, recover pituitary function after treatment, with gonadal and adrenal axes showing the highest likelihood.
Authors
- Pasqualino Malandrino (ORCID: https://orcid.org/0000-0003-2474-0954)
- Giorgio Arnaldi (ORCID: https://orcid.org/0000-0002-6204-3423)
- Antonio Prinzi (ORCID: https://orcid.org/0009-0002-7021-9860)
- Antonio Galvano (ORCID: https://orcid.org/0000-0003-4365-5683)
- Francesco Frasca (ORCID: https://orcid.org/0000-0002-5556-3201)
- Valentina Guarnotta
- Ginevra Fava
- Ignazio Bacchi
- Federica Spitali
Institutions
- Ospedale Garibaldi (IT)
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fendo.2025.1705300
- Citations
- 2
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.59