Nuclear accumulated µ-calpain enhances FoxO3a phosphorylation in AT2 cell and exacerbates pulmonary fibrosis
These data provide evidence that nuclear accumulation of µ-calpain is a critical step to elicit the aberrant AT2 cells differentiation and aggravate pulmonary fibrosis, which involves FoxO3a phosphorylation in an AKT-dependent manner.
Authors
- Yu-Tong Ye
- Luyao Han
- Miao-Feng Wang
- Jing‐Jun Zhou (ORCID: https://orcid.org/0000-0002-3487-5660)
- Linghui Pan
- Tian Yu (ORCID: https://orcid.org/0000-0002-2443-9961)
- Qiao Li (ORCID: https://orcid.org/0000-0003-4321-2647)
- Yi-Liang Zhu
- Shiyi Xu
- Yuan Fang
- Feng Zhao (ORCID: https://orcid.org/0000-0002-6612-1150)
- Jianming Wu (ORCID: https://orcid.org/0000-0002-6136-7469)
Institutions
- Southwest Medical University (CN)
- The First People's Hospital of Tianmen (CN)
- Xijing Hospital (CN)
Publication Details
- Journal
- Experimental Lung Research
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1080/01902148.2025.2583666
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00